Dr. Tanja Barger

CEO und Vorsitzende des Expetenkommitees ICANNA - International Institute for Cannabinol

VORTRAG: Autophagie - Recycling auf Zellebene und was Cannabis damit zu tun hat

Dr. Tanja Bagar ist eine Mikrobiologin mit einem Doktortitel in Biomedizin. Sie hat einen umfangreichen Erfahrungsschatz in der Forschung von Biotechnologie, molekularer Biologie und Zellsignalisierung in diversen Forschungseinrichtungen in Slowenien, Deutschland und dem Vereinigten Königreich. Ihr Hauptfokus liegt auf dem Endocannabinoid-System und aktiven Substanzen der Hanfpflanze.

Eine kurze Zusammenfassung ihres Vortrags in englischer Sprache:

Autophagy is an evolutionary self-cleaning program that takes place in our cells. The word autophagy literary means to eat oneself and comes from the Greek words auto, meaning self and phagy meaning eat. The word was coined by a Nobel Laureate: Christian de Duve a Belgian cell researcher who was awarded the Nobel Prize in 1974. In 2016 the Nobel prize was awarded to a Japanese researcher Yoshinori Ohsumi, who studied the process of autophagy in great detail. During the process of autophagy, damaged cellular components, unused proteins and other cellular waste are incorporated into a vesicle, called the autophagosome, similar as the domestic waste is packed up in bin bags. In humans the vesicles are transported to a lysosome - a cell organelle. These organelles have a similar function to a recycling plant: they decompose the materials included with the autophagosomes, so that the individual components can be reused. It is now evident that this process is vital for health and its disfunction is contributing to many pathological conditions.

With the understanding of the importance of autophagy lets see how cannabinoids effect it. Many studies reported that cannabinoids induce autophagy in healthy and tumor cells. It seems that in non-cancer cells cannabinoids can induce autophagy, as had been shown for brain, liver and colon cells. Cannabinoid, particularly CBD,  induced autophagy  was shown to contribute to better organ function and slower aging of the brain. In cancer it was shown that the way that cannabinoids interact with tumor cells is depend on the type of tumor and cannabinoid receptors specifics, but ultimately led to autophagy. The treatment with phytocannabinoids seems to cause an autophagic cell death, in which autophagy precedes apoptosis.  However the consequences of the activation of autophagy by cannabinoids are not yet fully understood. In some cases, autophagy acts as a death mechanism or it can act as a cytoprotective mechanism. So cannabinoids can act as inducers of protective or destructive cell processes and we will have a closer look at this in the Cultiva 2019 talk.

Vortrag in Englisch .


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